Antibody Humanization Service
AT A GLANCE
Technology/Methodology
Protein Design Labs’ (PDL) technology
Former PDL team members using algorithms developed by PDL work closely with PRI to design best-in-class humanized antibodies.
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Has your humanization technology been used for clinically evaluated products?
Yes, many times.
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IP situation / Freedom to Operate
Worldwide FTO; patents expired in 2014
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Terms
$75,000 (USD) in silico
$125,000 (USD) cell lines – 50% upfront
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(Clinical) validation
More than 250 mAbs have been humanized using the PDL technology.
15 out of the ~40 FDA-approved mAbs have been humanized using this method.
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What are typical timelines for humanization?
4-5 months
In silico analysis and sequences are available @ 1 month.
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Deliverables
What will we receive? e.g. sequence data, report etc.
Sequences and a report will be delivered upon completion of the project.
Commercial cell lines suitable for master cell banking are provided if the AMS technology is used.
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Any other considerations?
Sequences are routinely checked for potential immunogenicity and manufacturability.
Larix Bioscience LLC is a PRI spin-out company with the revolutionary AMS technology to identify high producing cell lines.
A high producing cell line (40-60 pg/cell/d) can be provided for an additional $250,000 (USD).
